Industry

3D printed Medical Device developed for rapid diagnosis of UTI

The estimated manufacturing cost of the Medical Device is an affordable Rs 608, and testing a single sample costs only Rs 8.

The Health Master

August 1, 2023

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Last Updated on January 2, 2024 by The Health Master

3D printed Medical Device

Indian Institute of Technology Guwahati (IIT Guwahati) has achieved a significant breakthrough in medical technology with the development of a cutting-edge Medical Device capable of swiftly and accurately detecting specific bacteria responsible for Urinary Tract Infections (UTIs).

Led by Dr. Partho Sarathi Gooh Pattader, the research team has created a Point-Of-Care Testing (POCT) prototype that promises to revolutionize the diagnosis and treatment of UTIs.

The UTI Detection Device:

The developed Medical Device is designed to offer the following features:

1. Fast, Accurate, and Reliable Detection:

The new Medical Device ensures rapid identification of the bacteria causing UTIs within just five minutes from a patient’s urine sample.

This swift detection enables timely treatment, reducing the patient’s suffering and mitigating the risk of severe complications that might arise from untreated UTIs.

2. Cost-Effective Solution:

The estimated manufacturing cost of the Medical Device is an affordable Rs 608, and testing a single sample costs only Rs 8.

This cost-effectiveness makes the medical device accessible to a broader range of healthcare facilities, potentially benefiting a larger segment of the population.

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Publication and Collaboration:

The research findings detailing the Point-Of-Care testing prototype have been published in the prestigious peer-reviewed journal, ACS Applied Bio Materials.

The paper features co-authors from IIT Guwahati, have contributed to this pioneering research, including:

Aniruddha Deb,
Dr. Partho Sarathi Gooh Pattader,
Prof. Tapas K Mandal,

Additionally, Dr. Swapnil Sinha and Mousumi Gogoi from Altanostic Lab Private Limited, IITG Research Park, have contributed to this pioneering research.

The Current Challenge and the Significance of the Research:

The conventional method of diagnosing UTIs through urine culture can take up to two days, causing significant delays in administering appropriate antibiotics.

This delay poses a serious problem as untreated UTIs can lead to life-threatening situations.

The newly developed Medical Device offers a breakthrough solution, enabling early-stage detection of UTIs caused by specific bacteria, such as ‘Klebsiella pneumoniae.’

Explaining the importance of the research, Dr. Pattader highlights that ‘Klebsiella pneumoniae’ is not only responsible for UTIs but can also lead to pneumonia and soft tissue infections.

Therefore, the device’s ability to identify this bacterium quickly is of critical importance in providing timely and life-saving treatment.

Working Mechanism:

The Medical Device employs gold nanoparticles with engineered aptamers to detect the target bacteria accurately.

Aptamers are specialized 3D puzzle pieces that only bind to the surface of specific bacteria.

When the aptamer-gold nanoparticles-bacteria combination occurs, the intensity of light changes, allowing detection through a UV-Visible Spectrophotometer.

This unique mechanism facilitates fast and accurate detection, benefiting primary healthcare significantly.

Funding and Future Prospects:

The research received funding support from esteemed institutions, including:

The Indian Council of Medical Research (ICMR),
Science and Engineering Research Board (SERB),
Department of Science and Technology (DST),
Ministry of Electronics & Information Technology (MeitY), Government of India.

With successful validation against hospital results, the technology is now poised for optimization and commercialization, aiming to benefit society as a whole.

Conclusion:

The development of the fast, accurate, and affordable Medical Device by IIT Guwahati’s research team marks a major advancement in medical technology.

By enabling early-stage detection of UTI-causing bacteria, the device promises to revolutionize UTI diagnosis and treatment, potentially saving lives and improving the overall healthcare landscape.

With strong collaboration and successful validation, the Medical Device is well-positioned for future commercialization and widespread use, serving the needs of countless patients in the coming years.

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